Revia

Basic Revia information

• INN (international nonproprietary name): Naltrexone hydrochloride
• Brand names available in the United Kingdom: Revia (original brand name); generic naltrexone 50 mg tablets
• ATC code: N07BB04
• Forms and dosages: 50 mg film-coated tablets
• Manufacturers in the United Kingdom: generic manufacturers such as Teva, Sandoz and Accord Healthcare
• Registration status in the United Kingdom: Prescription-only medicine (POM)
• OTC / Rx classification: Prescription-only medicine (POM)

Everyday use and best practices

Revia (naltrexone) is taken once daily, so consistency helps. Most patients take it in the morning, which fits easily into a daily routine and reduces the risk of forgetting a dose.

Taking with or without meals

Revia can be taken with or without food. Here are some tips:

• If taking in the morning, consider having it with breakfast to make it a part of your routine.
• For evening doses, ensure it's taken before your last meal to help minimise any potential stomach discomfort.

Safety priorities

Certain individuals should avoid Revia altogether. It can precipitate withdrawal symptoms in anyone who is still dependent on opioids or has opioids in the body, so patients must be opioid-free before starting. Anyone with acute hepatitis or severe liver impairment should also avoid this medication.

Activities to limit

Patients using Revia should proceed with caution, especially regarding activities requiring full attentiveness. Driving or operating machinery can be risky, as the medication may cause drowsiness or dizziness for some individuals. If your job involves safety-critical tasks, discuss your medication with a healthcare provider.

Dosage and adjustments

For adults, the typical dose is 50 mg orally once daily. Regular follow-ups with healthcare providers are vital to assess the ongoing effectiveness of the treatment and adjust dosages if necessary.

Special cases

Caution is especially needed when prescribing Revia to elderly patients or those with comorbidities. In these cases, liver and kidney functions must be considered. While adjustments may not always be necessary for elderly patients, they should be monitored closely to prevent adverse effects from Revia.

What’s inside and how it works

Revia tablets contain naltrexone hydrochloride together with inactive ingredients.

Ingredients overview

The primary active ingredient in Revia is naltrexone hydrochloride, which acts as an opioid receptor antagonist. This means it blocks the effects of opioids, helping to reduce cravings and prevent relapse. Inactive ingredients, often film-coating and fillers, ensure proper absorption and stability of the tablet.

Mechanism basics explained simply

Naltrexone works by binding to opioid receptors in the brain, preventing the euphoric effects that often trigger cravings. When individuals do not experience the reward typically associated with opioids or alcohol, they are less likely to relapse. This blockade allows those in recovery to focus on their treatment strategies without the overpowering pull of cravings.

Main indications

Naltrexone (Revia) is used as part of a treatment plan for people recovering from opioid dependence and, under specialist direction, for alcohol dependence.

Approved uses (MHRA listing)

In the UK, naltrexone is licensed as an adjunct in the maintenance of abstinence in detoxified, formerly opioid-dependent patients. Its use in alcohol dependence is recommended by NICE guidance but is outside the product licence (off-label).

Off-label uses in UK clinics

Other addiction-related uses are specialist decisions made after a discussion of the benefits and risks.

Interaction warnings

Take note of the following interactions while taking Revia.

Food interactions (alcohol, tea/coffee)

Alcohol is best avoided while taking Revia, particularly by people being treated for opioid dependence, and it may worsen drowsiness or dizziness. Caffeine from tea and coffee could heighten anxiety, a possible side effect of naltrexone, so it is wise to watch overall consumption.

Drug conflicts

Potential drug interactions can occur with opioids, which should be avoided as they can trigger acute withdrawal symptoms. Other medicines that may interact include thioridazine. Patients should always inform healthcare providers of their current medications.

Alternative choices

Alternatives used in the NHS include the following.

Regulation snapshot

The Medicines and Healthcare products Regulatory Agency (MHRA) oversees the approval of medicines in the UK. Revia, which contains naltrexone hydrochloride, is a prescription-only medicine (POM) that requires a healthcare professional's oversight for safe use. Generic naltrexone tablets are available.

Within the NHS, naltrexone is prescribed in line with national guidance for the treatment of alcohol and opioid dependence, as part of comprehensive treatment plans that often involve psychosocial support. Prescribers monitor patients closely, especially those with liver impairment, and liver function tests are advised.

Frequently asked questions

Many patients have questions about Revia and its use in opioid and alcohol dependence. One common question is about the dose. The standard recommendation is 50 mg taken orally once daily for adults, but individual needs may vary based on health conditions and treatment goals. It's essential to consult a healthcare provider to determine the right dosage.

Another common question is how long treatment lasts. For alcohol dependence it typically runs for at least three to six months, with regular reassessment. Patients are encouraged to discuss their progress and any side effects with their healthcare professionals.

Guidelines for proper use

UK pharmacist counselling style

A pharmacist's counselling on Revia might cover key aspects such as:

• How to take Revia correctly: dose timing and adherence
• The importance of avoiding opioid use while on naltrexone to prevent withdrawal symptoms
• Potential side effects and what to do if they arise
• Strategies for integrating Revia into a broader treatment plan that includes therapy and support groups

NHS patient support advice

The NHS offers various resources to support patients on Revia:

• Access to local addiction support services, which often provide additional counselling and support groups.
• Information on lifestyle changes and coping strategies relevant to alcohol or opioid dependence.
• Guidance on how to manage potential side effects experienced during treatment.

Patients are encouraged to use these resources alongside their treatment with Revia and to keep in touch with their healthcare professionals.

Delivery information