Disulfiram
In stock
250mg · 500mg
from 31,47 £
In brief
- Disulfiram at Pharmacy London24 is a 250mg tablet in packs of 30, 60, 90, 120, 180 or 360, or a 500mg tablet in packs of 30, 60, 90, 120 or 180, delivered across the UK in 9–21 days.
- The medicine blocks the enzyme that clears acetaldehyde, so a drink taken during treatment triggers flushing, nausea, a racing pulse and anxiety; that deterrent effect supports someone who is already committed to staying off alcohol, usually together with counselling.
- Neither 250mg nor 500mg is a UK-licensed strength, as British tablets contain 200 mg; the supervising doctor sets the amount, often starting with a brief higher phase before settling on a smaller daily dose.
- Hidden alcohol in mouthwashes, cough mixtures, sauces, vinegar-based foods and perfumed products can provoke a reaction, so avoid it throughout treatment and for 14 days after the final tablet.
- Anyone with heart failure, coronary artery disease or a history of psychotic illness should steer clear; report jaundice, persistent tiredness or tingling in the limbs promptly. It is a UK POM.
Basic disulfiram information
- INN (international nonproprietary name): Disulfiram
- Brand names available in the United Kingdom: Antabuse
- ATC code: N07BB01
- Forms and dosages: Tablets 200 mg (Antabuse)
- Registration status in the United Kingdom: Prescription-only medicine (POM)
- OTC / Rx classification: Prescription-only medicine (POM)
Everyday use and best practices
Disulfiram, commonly known by its brand name Antabuse, is used in the treatment of chronic alcohol dependence.Morning vs evening dosing
Disulfiram is taken once daily, at a time that suits you. Many people take it in the morning to establish a consistent routine.Taking with or without meals
Disulfiram can be taken with or without food, which offers flexibility in how to integrate it into daily life. Taking it with a regular meal may help reinforce a routine. Some individuals may experience mild stomach upset, so it may be necessary to adjust timing for comfort.- Consistency is key: Choose a time that fits best into your routine.
- If sensitive, adjust dosage timing with meals to minimise stomach upset.
- Engage with healthcare professionals to optimise dosing strategies according to individual needs.
Legal status in the UK
Disulfiram is a prescription-only medicine (POM) in the UK.
What’s inside and how it works
Disulfiram tablets contain the active ingredient disulfiram. This compound inhibits the enzyme aldehyde dehydrogenase. The tablets also contain inactive ingredients (excipients), which are listed in the patient information leaflet; this matters for patients with allergies or sensitivities. Disulfiram blocks the body's ability to break down alcohol. If alcohol is consumed while taking disulfiram, acetaldehyde builds up, resulting in unpleasant effects such as flushing, palpitations, and nausea. This strong aversion becomes a crucial aspect of its effectiveness in combating alcohol dependence.Main indications
Disulfiram, known by its brand name Antabuse, is used as part of a comprehensive treatment plan aimed at supporting recovery from alcohol dependence.Approved uses (MHRA listing)
Disulfiram is indicated as an adjunct in the treatment of chronic alcohol dependence, for individuals who are abstinent and taking part in a structured rehabilitation programme. It is not suitable for those undergoing acute alcohol withdrawal or still drinking. Patients must remain abstinent from alcohol for at least 12 hours before beginning treatment to avoid the severe disulfiram-alcohol reaction, which can cause symptoms like flushing, nausea, and heart palpitations.Off-label uses in UK clinics
The decision to use disulfiram outside its licensed indication should be made by a specialist clinician, based on a careful assessment of the risks and benefits.| City | Region | Delivery Time |
|---|---|---|
| London | Greater London | 9–21 days |
| Birmingham | West Midlands | 9–21 days |
| Manchester | Greater Manchester | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Leeds | West Yorkshire | 9–21 days |
| Sheffield | South Yorkshire | 9–21 days |
| Bristol | Bristol | 9–21 days |
| Newcastle | Tyne and Wear | 9–21 days |
| Coventry | West Midlands | 9–21 days |
| Cardiff | Wales | 9–21 days |
| Nottingham | Nottinghamshire | 9–21 days |
| Leicester | Leicestershire | 9–21 days |
| Brighton | East Sussex | 9–21 days |
| Southampton | Hampshire | 9–21 days |
| Exeter | Devon | 9–21 days |
