Metronidazole
In brief
- In our pharmacy, you can buy metronidazole without a prescription, with delivery in 9–21 days throughout the United Kingdom. Discreet and anonymous packaging.
- Metronidazole is used for the treatment of anaerobic infections, trichomoniasis, bacterial vaginosis, amoebiasis, giardiasis, and rosacea. The drug acts by disrupting DNA synthesis in bacteria and protozoa.
- The usual dosage of metronidazole varies: for anaerobic infections, it is typically 400 mg by mouth every 8 hours (500 mg intravenously in hospital), for trichomoniasis 2 g once, and for bacterial vaginosis 400 mg twice daily for 5–7 days.
- The form of administration includes tablets, oral suspension, intravenous infusion (hospital use), topical gels and vaginal gel.
- The effect of the medication begins within 1-2 hours for oral forms.
- The duration of action is approximately 8 hours for oral doses.
- Do not consume alcohol while taking metronidazole.
- The most common side effects include nausea, a metallic taste, vomiting, and diarrhoea.
- Would you like to try metronidazole without a prescription?
Basic metronidazole information
- INN (international nonproprietary name): Metronidazole
- Brand names available in the United Kingdom: Flagyl; generic metronidazole
- ATC code: J01XD01
- Forms and dosages: Tablets 200 mg, 400 mg; oral suspension; intravenous infusion (hospital use); topical gels (0.75%); vaginal gel (0.75%)
- Registration status in the United Kingdom: Prescription-only medicine (POM)
- OTC / Rx classification: Prescription-only medicine (POM)
Everyday use and best practices
Understanding the dosage timing and the interaction with alcohol is essential when taking metronidazole.
Morning vs evening dosing
Metronidazole is usually taken two or three times a day, or as a single dose for some infections, as directed by the prescriber. Doses should be evenly spaced through the day. Consistency is key; if nausea arises, taking the medication with food can help.
Taking with or without meals (UK diet habits)
Food has little effect on how much metronidazole is absorbed:
- With meals: Taking metronidazole with or after a meal can help reduce gastrointestinal side effects like nausea.
- Without meals: If taken on an empty stomach, it may be absorbed slightly faster, but this could lead to increased stomach upset.
If a patient experiences discomfort, it is recommended to take metronidazole with food. Maintaining the same routine daily ensures consistent levels of the medication in the bloodstream.
Patients are advised to consult their healthcare professional for personalised recommendations on dosage timing and the best way to take metronidazole according to their specific treatment plan and lifestyle.
What’s inside and how it works
Metronidazole is a medicine used to treat infections caused by anaerobic bacteria and certain parasites. Its components include:
- Metronidazole: The main active ingredient, working against anaerobic bacteria and protozoa.
- Excipients: Various inert substances in tablet formulations enhance stability and absorption.
Metronidazole disrupts the DNA synthesis of target organisms, leading to cell death. The anaerobic bacteria, which thrive in low-oxygen environments like certain infections in the gut and mouth, are particularly sensitive to this disruption. This selective action helps eliminate the pathogens while sparing many aerobic (oxygen-dependent) bacteria, making metronidazole effective for treating conditions such as bacterial vaginosis and giardiasis.
Main indications
In the UK, metronidazole is licensed for several conditions:
- Trichomoniasis: A sexually transmitted infection caused by protozoan parasites.
- Bacterial vaginosis: An imbalance of bacteria in the vagina.
- Anaerobic infections: Infections occurring without oxygen, often in dental and gut contexts.
Outside of these approved uses, metronidazole is sometimes used off-label for conditions such as certain gastrointestinal infections (topical metronidazole is licensed for rosacea).
Interaction warnings
When taking metronidazole, attention to dietary interactions is crucial:
- Alcohol: Consuming alcohol during treatment can lead to severe reactions, including flushing, nausea, and increased heart rate due to a disulfiram-like effect.
In terms of drug interactions, notable conflicts may arise with:
- Warfarin: Increased anticoagulant effects, risking excessive bleeding.
- Lithium and phenytoin: Metronidazole may raise blood levels and increase the risk of toxicity.
These interactions necessitate consultation with a healthcare provider to tailor safe management strategies.
Alternative choices
When considering alternatives to metronidazole for treating infections, healthcare providers might consider:
- Clindamycin: Effective against similar infections but with distinct side effects.
- Tinidazole: Often used interchangeably with metronidazole for trichomoniasis, its side effects are similar but may differ in efficacy against certain pathogens.
The choice depends on the infection, side effect profile and patient history.
Regulation snapshot
Metronidazole has antibacterial and antiprotozoal properties. In the UK it is licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) and oral metronidazole is a prescription-only medicine (POM). Patients are advised to consult their pharmacists for guidance on this medication, particularly about alcohol.
Frequently asked questions
Can I drink alcohol while on metronidazole?
It is strongly advised to avoid alcohol during treatment and for 48 hours afterwards, as it may cause adverse effects like nausea and vomiting.
What happens if I accidentally drink alcohol during treatment?
Drinking alcohol on metronidazole can lead to a disulfiram-like reaction, resulting in severe discomfort.
Are there any food restrictions while taking metronidazole?
Generally, no specific food restrictions are necessary, but alcohol should be avoided.
How should I take metronidazole for bacterial vaginosis?
Dosages vary, and it's crucial to follow the prescribed regimen, typically involving a 5–7 day treatment period (or a single larger dose in some cases).
Guidelines for proper use
Key recommendations from pharmacists:
- Dosage adherence: Patients must adhere strictly to prescribed dosages, typically 200 mg to 500 mg per dose, depending on the indication.
- Counsel on alcohol interaction: Highlighting the potential adverse reactions linked to alcohol consumption while on metronidazole is essential.
- Monitor side effects: Patients should be advised to report any unusual side effects like dizziness or gastrointestinal discomfort.
- Storage advice: Medications should be stored at room temperature away from excessive heat and moisture.
The NHS website and NHS 111 provide further information on metronidazole and its proper use.
| City | Region | Delivery Time |
|---|---|---|
| London | England | 9–21 days |
| Birmingham | England | 9–21 days |
| Manchester | England | 9–21 days |
| Liverpool | England | 9–21 days |
| Leeds | England | 9–21 days |
| Sheffield | England | 9–21 days |
| Bristol | England | 9–21 days |
| Cardiff | Wales | 9–21 days |
| Edinburgh | Scotland | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Newcastle | England | 9–21 days |
| Nottingham | England | 9–21 days |
| Brighton | England | 9–21 days |
| Southampton | England | 9–21 days |
| Belfast | Northern Ireland | 9–21 days |
