Methotrexate
In brief
- In our pharmacy, you can buy methotrexate without a prescription, with delivery in 9–21 days throughout the United Kingdom. Discreet and anonymous packaging.
- Methotrexate is intended for the treatment of cancer, autoimmune diseases, and psoriasis. The drug acts as an antimetabolite and folic acid analogue.
- The usual dose of methotrexate varies depending on the treatment; for rheumatoid arthritis and psoriasis it is commonly 7.5 mg to 25 mg ONCE a week (never daily).
- The form of administration includes oral tablets, oral solutions, and injections.
- The effect of the medication begins within weeks, depending on the condition being treated.
- Do not consume alcohol while using methotrexate.
- The most common side effect is nausea.
- Would you like to try methotrexate without a prescription?
Basic methotrexate information
- INN (international nonproprietary name): Methotrexate
- Brand names available in the United Kingdom: Jylamvo, Maxtrex, Metoject, Nordimet and generic methotrexate
- ATC code: L01BA01
- Forms and dosages: Oral tablets 2.5 mg and 10 mg; oral solution 2 mg/ml (Jylamvo); pre-filled syringes/pens (Metoject, Nordimet); injection (vials and ampoules)
- Manufacturers in the United Kingdom: Pfizer (Maxtrex), medac (Metoject), Nordic Pharma (Nordimet) and generic manufacturers
- Registration status in the United Kingdom: Licensed by the MHRA; prescription-only medicine (POM)
- OTC / Rx classification: Prescription-only medicine (POM)
Everyday use and best practices
Morning vs evening dosing
In the management of conditions such as rheumatoid arthritis and psoriasis, methotrexate is taken ONCE A WEEK, on the same day each week, never daily (taking it daily by mistake can be fatal), with common dosages ranging from 10 mg to 25 mg. Many patients ask whether it is better to take their dose in the morning or evening.- Morning dosing fits easily into a daily routine.
- Evening dosing is often preferred by those who experience fatigue or nausea as side effects, as they may be able to sleep through any discomfort.
Taking with or without meals
Methotrexate tablets can be taken with or without food.- If nausea occurs, consider taking it with a light meal that is low in fat, which may help reduce side effects. Foods such as toast or crackers are good options.
- Linking your weekly dose to a particular day, for example a Sunday, can make it easier to remember.
Always check with your healthcare provider before making dietary changes alongside methotrexate.
Common questions about methotrexate
Common questions about methotrexate:
Can you drink alcohol while taking methotrexate?
It is advised to limit or avoid alcohol while on methotrexate. Combining alcohol with this medication can increase the risk of liver damage, as methotrexate itself can affect liver function. If you do choose to drink, discuss safe limits with your healthcare provider.
What should I expect in terms of side effects?
Side effects can vary, but they commonly include:
- Nausea and vomiting
- Fatigue
- Diarrhoea
- Mouth ulcers
- Hair loss
Severe side effects such as liver damage or lung problems are less common. Regular blood tests are necessary to monitor blood counts and kidney and liver function while on methotrexate, so that any problems are caught early. Suspected side effects can be reported through the Yellow Card scheme.
Is methotrexate safe to use during pregnancy?
No. Methotrexate must not be used during pregnancy as it can cause birth defects and other serious complications. Effective contraception is needed during treatment and for a period afterwards (for both women and men), and you should ask your specialist how long. If a pregnancy occurs unexpectedly while on methotrexate, contact a healthcare provider immediately.
Is methotrexate available without a prescription?
No – in the UK methotrexate is a prescription-only medicine.
Can methotrexate affect my immune system?
Yes, methotrexate can suppress the immune system, making patients more susceptible to infections. Patients should remain vigilant about hygiene and report signs of infection such as fever or sore throat promptly. Vaccinations may be recommended to help protect against infections; live vaccines should be avoided.
| City | Region | Delivery Time |
|---|---|---|
| London | England | 9–21 days |
| Birmingham | England | 9–21 days |
| Manchester | England | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Liverpool | England | 9–21 days |
| Bristol | England | 9–21 days |
| Sheffield | England | 9–21 days |
| Newcastle | England | 9–21 days |
| Cardiff | Wales | 9–21 days |
| Edinburgh | Scotland | 9–21 days |
| Nottingham | England | 9–21 days |
| Leeds | England | 9–21 days |
| Coventry | England | 9–21 days |
| Wolverhampton | England | 9–21 days |
| Derby | England | 9–21 days |
