Metformin
In stock
500mg · 850mg · 1000mg
from 26,78 £
In brief
- In our pharmacy, you can buy metformin without a prescription, with delivery in 9–21 days throughout the United Kingdom. Discreet and anonymous packaging.
- Metformin is used for the treatment of type 2 diabetes and polycystic ovary syndrome. The drug primarily works by decreasing hepatic glucose production and increasing insulin sensitivity.
- The usual starting dose of metformin for adults with type 2 diabetes is 500 mg once or twice daily, increased gradually to a maximum of 2000 mg per day.
- Metformin is available as immediate-release and modified-release tablets, as well as an oral solution.
- Avoid drinking excessively while taking metformin because of the risk of lactic acidosis.
- The most common side effects include gastrointestinal upset such as nausea, diarrhoea, and abdominal pain.
- Would you like to try metformin without a prescription?
Basic metformin information
- INN (international nonproprietary name): Metformin
- Brand names available in the United Kingdom: Glucophage, Glucophage SR and generic metformin
- ATC code: A10BA02
- Forms and dosages: Tablets (500 mg, 850 mg, 1000 mg), Extended-release tablets (500 mg, 750 mg, 1000 mg), Oral solution (100 mg/mL)
- Manufacturers in the United Kingdom: Merck (Glucophage) and generic manufacturers such as Teva, Sandoz and Aristo Pharma
- Registration status in the United Kingdom: MHRA-approved; prescription-only medicine (POM)
- OTC / Rx classification: Prescription-only medicine (POM)
Morning vs evening dosing
Metformin is usually taken with meals. Many people prefer to take their medication in the morning, particularly when it's aligned with breakfast, which helps to mitigate any gastrointestinal side effects that may occur on an empty stomach. Adherence to prescribed dosing schedules, whether in the morning or evening, supports better control of blood glucose levels, ensuring that the medication can work effectively throughout the day or night.
Taking with or without meals
To minimise gastrointestinal side effects, it is highly recommended that metformin be taken with food. Taking it with meals reduces the risk of stomach upset, and taking it at regular times helps to keep blood glucose control steady. Without food, symptoms such as bloating or diarrhoea are more likely.
What’s inside and how it works
Ingredients overview
Metformin's active ingredient, metformin hydrochloride, is a member of the biguanide class. Its primary role in glucose management is to improve insulin sensitivity, making cells more adept at using glucose for energy. Tablets also contain excipients such as magnesium stearate.
Mechanism basics explained simply
This oral hypoglycaemic agent exerts its effects primarily by enhancing insulin sensitivity and reducing hepatic glucose production. Metformin encourages the body's cells to take up glucose more efficiently, thus lowering blood sugar levels. Additionally, it attenuates glucose output from the liver, contributing to overall glucose homeostasis.
Main indications
Approved uses
Metformin is licensed in the UK for treating type 2 diabetes, particularly in overweight patients, alongside diet and exercise.
Off-label uses in UK clinics
Healthcare professionals sometimes prescribe metformin for off-label uses, notably in managing polycystic ovary syndrome (PCOS). While beneficial, such applications should be approached with medical supervision to monitor effects and potential side effects effectively.
Interaction warnings
Food interactions
Awareness of food and drink interactions is vital while taking metformin. Drinking excessive alcohol can increase the risk of lactic acidosis and worsen gastrointestinal side effects.
Drug conflicts
Check with a healthcare professional before starting new medicines alongside metformin. Drugs such as diuretics and corticosteroids can affect blood glucose control, and iodinated contrast media and medicines that affect kidney function need special care.
Alternative choices
Other medicines for type 2 diabetes can be used instead of, or alongside, metformin. Each has its own benefits and drawbacks, which should be discussed with a healthcare professional.
NHS prescribing alternatives
Commonly considered alternatives to metformin include:
- Glitazones (e.g. pioglitazone): Can improve insulin sensitivity but carries a risk of weight gain and fluid retention.
- SGLT2 inhibitors (e.g. dapagliflozin): Can help with weight loss but may increase the risk of genital and urinary tract infections.
- GLP-1 receptor agonists (e.g. liraglutide): Can help with weight loss but may cause gastrointestinal side effects.
Regulation snapshot
In the UK, metformin is a prescription-only medicine (POM) licensed by the MHRA (Medicines and Healthcare products Regulatory Agency). NICE guidance recommends it as first-line treatment for type 2 diabetes, and prescribers consider factors such as kidney function before starting it.
Frequently asked questions
Here are some frequently asked questions regarding metformin's use:
- Can I drink alcohol while taking metformin?
Avoid drinking excessively, as alcohol can increase the risk of lactic acidosis and other side effects. - What should I do if I miss a dose of metformin?
Take the missed dose as soon as you remember unless it's almost time for your next dose. Never double up. - Can people without diabetes take metformin?
It is sometimes prescribed off-label for PCOS, but only under medical supervision. - What are the side effects of metformin?
Common side effects include gastrointestinal issues, while rare but severe side effects include lactic acidosis.
Guidelines for proper use
To maximise the effectiveness of metformin while minimising side effects, consider the following best practices:
- Always take metformin with food to reduce gastrointestinal discomfort.
- Do not skip doses; maintain a consistent schedule.
- Monitor blood glucose levels as advised by healthcare providers.
- Stay hydrated and discuss any renal issues with a healthcare professional.
For more detailed information about metformin and managing diabetes, visit NHS Resources.
| City | Region | Delivery time |
|---|---|---|
| Liverpool | Merseyside | 9–21 days |
| Birmingham | West Midlands | 9–21 days |
| London | Greater London | 9–21 days |
| Manchester | Greater Manchester | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Bristol | Bristol | 9–21 days |
| Leeds | West Yorkshire | 9–21 days |
| Swansea | Swansea | 9–21 days |
| Cardiff | Wales | 9–21 days |
| Edinburgh | Scotland | 9–21 days |
| Coventry | West Midlands | 9–21 days |
| Sheffield | South Yorkshire | 9–21 days |
