Glucophage Sr

Basic Glucophage SR information

• INN (international nonproprietary name): Metformin hydrochloride
• Brand names available in the United Kingdom: Glucophage SR; generic metformin prolonged-release tablets
• ATC code: A10BA02
• Forms and dosages: Prolonged-release tablets 500 mg, 750 mg and 1000 mg, taken orally
• Manufacturers in the United Kingdom: Merck (Glucophage SR) and generic manufacturers
• Registration status in the United Kingdom: Prescription-only medicine (POM)
• OTC / Rx classification: Prescription-only medicine (POM)

Everyday use and best practices

Glucophage SR (metformin prolonged-release) is usually taken once daily. It is often taken with the evening meal to reduce the likelihood of gastrointestinal side effects, but some people take it with breakfast, so follow your healthcare provider's instructions.

Morning vs evening dosing

Whether to take Glucophage SR in the morning or evening depends on your routine and your prescriber's advice. Swallow the tablet whole with a drink of water and do not crush or chew it.

Taking with or without meals

To minimise gastrointestinal distress, take Glucophage SR with food. A balanced diet complements the medication's effectiveness, and regular consultations with healthcare professionals can guide dietary adjustments that fit your treatment plan.

What’s inside and how it works

Ingredients overview

The active ingredient in Glucophage SR is metformin hydrochloride, a biguanide that improves insulin sensitivity and helps to manage blood glucose levels. The prolonged-release formulation releases the active ingredient gradually, which allows once-daily dosing.

Mechanism basics explained simply

Metformin has a dual action to combat high blood sugar levels. It reduces glucose production in the liver while enhancing insulin sensitivity in cells. This lowers blood sugar with a low risk of hypoglycaemia when metformin is used on its own.

Main indications

Approved uses (MHRA listing)

Glucophage SR is licensed in the UK for the management of type 2 diabetes in adults, especially in overweight patients, alongside diet and exercise. The typical starting dosage is 500 mg once daily, with gradual increases as needed.

Off-label uses in UK clinics

While Glucophage SR is primarily used for diabetes management, some clinicians may prescribe it for conditions like polycystic ovary syndrome (PCOS).

Always consult a healthcare professional before considering off-label uses to ensure it aligns with individual health needs.

Interaction warnings

Food interactions (alcohol)

• Drinking excessive amounts of alcohol increases the risk of lactic acidosis while on this medication.

Drug conflicts

Consult your doctor or pharmacist regarding any medicines you take. Certain drugs, especially those that may affect kidney function, and iodinated contrast agents, can pose risks when taken with Glucophage SR, and other diabetes medicines may need dose adjustment.

Suspected side effects can be reported through the MHRA Yellow Card scheme.

Regulation snapshot

Glucophage SR is a prescription-only medicine (POM) in the UK.

Delivery information