Domperidone
In brief
- You can purchase domperidone in our pharmacy without a prescription, with delivery available throughout the United Kingdom. Discreet and anonymous packaging is assured.
- Domperidone is used for the treatment of nausea and vomiting. It works as a peristaltic stimulant and antiemetic by blocking dopamine receptors in the gut.
- The usual dosage for adults is 10 mg taken three times a day.
- The form of administration includes film-coated tablets and oral suspension.
- The onset time for domperidone is usually within 30 to 60 minutes.
- The duration of action is approximately 4 to 6 hours.
- Alcohol should be avoided while taking domperidone.
- The most common side effect is dry mouth.
- Would you like to try domperidone without a prescription?
Basic domperidone information
- INN (international nonproprietary name): Domperidone
- Brand names available in the United Kingdom: Motilium; generic domperidone
- ATC code: A03FA03
- Forms and dosages: Tablets 10 mg; oral suspension 1 mg/mL
- Manufacturers in the United Kingdom: Janssen and generic manufacturers
- Registration status in the United Kingdom: Prescription-only medicine (POM)
- OTC / Rx classification: Prescription-only medicine (POM)
Everyday use and best practices
Domperidone is usually taken up to three times a day, about 15 to 30 minutes before meals, as directed by the prescriber. Maintain consistency in the timing of each dose.
Taking with or without meals
Domperidone can be taken with or without food, but taking it before meals is generally more effective, because it is absorbed more quickly on an empty stomach.
Heavy, rich meals might still induce nausea, even with treatment, so lighter meals may help.
What’s inside and how it works
The active ingredient is domperidone (as domperidone maleate). The medicine is supplied as film-coated tablets of 10 mg, or as an oral suspension of 1 mg/mL, depending on the manufacturer.
Domperidone is an antiemetic that works by blocking dopamine receptors, mainly in the gut and in the area of the brain that triggers nausea. This reduces the feeling of nausea and enhances gut movement.
Main indications
Domperidone is primarily indicated for treating nausea and vomiting.
Approved uses (MHRA listing)
Domperidone is licensed in the UK for the relief of the symptoms of nausea and vomiting, in adults and in adolescents weighing 35 kg or more. Because of the risk of heart rhythm problems, it is used at the lowest effective dose for the shortest possible time, usually not longer than one week.
Off-label uses in UK clinics
Some healthcare professionals may prescribe domperidone off-label. Uses outside its licence include:
- Gastroparesis management
- Enhancing lactation in breastfeeding mothers
Such off-label treatments should be carefully weighed for their benefits and risks by the patient and healthcare provider.
Interaction warnings
Food interactions (alcohol, tea/coffee)
Certain foods and drinks can influence the effectiveness and side effects of domperidone. For instance, alcohol could amplify side effects like dizziness and drowsiness, and antacids or acid-reducing medicines taken at the same time can reduce the absorption of domperidone, so these should be taken separately.
Drug conflicts
Domperidone must not be combined with medicines that prolong the QT interval or with strong CYP3A4 inhibitors (examples include certain antibiotics, antifungals and antidepressants) because of the risk of serious heart rhythm problems. Tell your healthcare provider about all your medicines. Suspected side effects can be reported through the Yellow Card scheme.
Alternative choices
Alternatives to domperidone prescribed on the NHS include metoclopramide and ondansetron, each with its own benefits and drawbacks.
| Alternative | Pros | Cons |
|---|---|---|
| Metoclopramide | Effective antiemetic | Can cause drowsiness and movement disorders; short-term use only |
| Ondansetron | Well-tolerated | Can cause constipation; mainly used for chemotherapy- and post-operative nausea |
Discuss with your healthcare provider which option suits your needs and medical history.
Regulation snapshot
Domperidone is a prescription-only medicine (POM) in the UK, regulated by the MHRA because of its associated cardiac risks. Doctors must carefully assess the need for domperidone for each individual patient. Doses and indications are defined based on safety data, particularly regarding cardiac health.
Frequently asked questions
Common questions about domperidone:
- Can I buy domperidone over the counter?
No, it’s prescription-only in the UK. - Is domperidone safe during pregnancy?
Consultation with a GP is necessary, as a risk versus benefit assessment must be made. - How fast does domperidone work?
Symptom relief is usually felt within 30 to 60 minutes of taking the medicine. - Can I take domperidone with other medications?
Always check with a healthcare provider to avoid drug interactions.
Guidelines for proper use
UK pharmacist counselling style
Pharmacists advise on the timing and dosage of domperidone and on interactions to avoid, and counsel patients on its potential side effects.
NHS patient support advice
Keep open communication with your healthcare providers. The patient information leaflet supplied with the medicine gives full information on its use.
Delivery information
| City | Region | Delivery time |
|---|---|---|
| London | Greater London | 9–21 days |
| Birmingham | West Midlands | 9–21 days |
| Manchester | North West | 9–21 days |
| Leeds | West Yorkshire | 9–21 days |
| Glasgow | Scotland | 9–21 days |
| Cardiff | Wales | 9–21 days |
| Newcastle | North East | 9–21 days |
| Bristol | South West | 9–21 days |
| Sheffield | South Yorkshire | 9–21 days |
| Nottingham | East Midlands | 9–21 days |
| Leicester | Leicestershire | 9–21 days |
| Wolverhampton | West Midlands | 9–21 days |
