Ciprofloxacin + Dexamethasone

Basic ciprofloxacin + dexamethasone information

• International nonproprietary name (INN): Ciprofloxacin and dexamethasone
• Brand names available in the United Kingdom: Cilodex
• ATC code: S02CA06
• Forms and dosages: Ear drops, suspension (ciprofloxacin 0.3% / dexamethasone 0.1%)
• Manufacturers in the United Kingdom: Alcon
• Registration status in the United Kingdom: Prescription-only medicine (POM)
• OTC / Rx classification: Prescription-only medicine (POM)

Everyday use and best practices

Ciprofloxacin and dexamethasone ear drops are used in the affected ear only. The usual dose is 4 drops in the affected ear twice daily for 7 days, and the full course should be completed even if symptoms improve.

Morning vs evening dosing

The drops are usually used in the morning and evening, about 12 hours apart. Regardless of the chosen times, the key lies in consistency, which helps the treatment work and prevents forgotten doses.

Taking with or without meals

Because the drops are applied to the ear and not swallowed, meals make no difference. Warm the bottle in your hand for a minute or two before use and shake it well. Lie with the affected ear upwards for about a minute after putting the drops in so that they reach the infected area.

What’s inside and how it works

The combination of ciprofloxacin and dexamethasone is used for ear infections with inflammation.

Ingredients overview

Ciprofloxacin is a broad-spectrum antibiotic from the fluoroquinolone class, primarily targeting bacterial infections in the ear. It disrupts bacterial DNA synthesis, killing the bacteria. Dexamethasone is a corticosteroid that reduces inflammation and alleviates pain. Together, they treat the bacterial infection and relieve discomfort.

Mechanism basics explained simply

In simple terms, ciprofloxacin tackles the bacteria causing the infection, while dexamethasone calms the irritation and swelling in the ear.

Main indications

Approved uses

This combination is licensed in the UK for acute otitis externa (swimmer’s ear) and for acute otitis media in patients with tympanostomy tubes (grommets). These infections can cause intense discomfort and are often accompanied by inflammation.

Off-label uses in UK clinics

Beyond the licensed indications, clinicians may occasionally prescribe it off-label, for example for other ear infections or post-operative ear infections, based on clinical judgement.

Interaction warnings

Food interactions

Because the drops are used in the ear, food and drink have little effect on this medication.

Drug conflicts

Very little of the medicine is absorbed into the body from the ear, so interactions are unlikely. Patients should still tell healthcare providers about all other ear drops and medicines they are using.

Alternative choices

Other ear drops that may be prescribed by the NHS include:

• Ofloxacin ear drops: antibiotic only, with no anti-inflammatory component.
• Ciprofloxacin ear drops (without a steroid): antibiotic only.
• Neomycin, polymyxin B and hydrocortisone ear drops: broad-spectrum antibiotic with a steroid, but not suitable for all types of infection.

A healthcare professional can advise which option is most appropriate.

Regulation snapshot

The MHRA (Medicines and Healthcare products Regulatory Agency) regulates ciprofloxacin and dexamethasone ear drops in the UK.

The combination is a prescription-only medicine (POM). This ensures that patients receive an appropriate evaluation before starting treatment.

Frequently asked questions

What is ciprofloxacin + dexamethasone used for?
It's typically prescribed for treating acute otitis media and externa, addressing both infection and inflammation.

Can I buy ciprofloxacin + dexamethasone without a prescription?
No. In the UK, this medication is prescription-only.

What should I do if I miss a dose?
Use it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double up.

Are there any side effects?
Common side effects may include ear discomfort, itching and changes in taste. If severe reactions occur, consult a healthcare professional.

Guidelines for proper use

UK pharmacist counselling style

Pharmacists will clarify the application process, possible side effects and any warnings regarding interactions, so that patients feel informed and comfortable with their treatment.

NHS patient support advice

The NHS provides information leaflets and online guidance, and patients can contact NHS 111 for any queries.